6. March 18, 2010 -- round of 64
No. 14 Ohio Bobcats vs. No. 3 Georgetown Hoyas
Closing line: Georgetown minus-13.5
The Bobcats' starting backcourt of D.J. Cooper and Armon Bassett combined for 55 points as they dominated the favored Hoyas. They led 48-36 at halftime and held a lead of at least seven points for the entire second half. Their 97 points remain the most ever by a team seeded 13th or lower in the tournament.
Final score: Ohio 97, Georgetown 83
7. March 18, 2005 -- round of 64
No. 14 Bucknell Bison vs. No. 3 Kansas Jayhawks
Closing line: Kansas minus-13.5
This upset was more than just a 13.5-point spread -- it pitted one of college basketball's blue bloods against a small school in central Pennsylvania. Kansas was the preseason No. 1 going into the 2004-05 season, and it had won at least one game in each of its previous 15 tournaments. Bucknell, on the other hand, had lost its only two tournament games in school history by an average of 27.5 PPG. None of that mattered on this Friday night in Oklahoma City. The Bison's Chris McNaughton rattled in a hook shot with 10.5 seconds left, and Bucknell survived a pair of potential game-winners from Kansas to pull off the shocker.
Final score: Bucknell 64, Kansas 63
8. March 21, 2014 -- round of 64
No. 14 Mercer Bears vs. No. 3 Duke Blue Devils
Closing line: Duke minus-13
For the second time in three seasons, Duke was upset as a double-digit round-of-64 favorite. In 2012, C.J. McCollum and Lehigh beat Duke as a 12-point underdog. This time, it was Atlantic Sun Conference champion Mercer knocking off Duke. The Bears came back from five points down with 4:40 to go, finishing the game on a 20-8 run. It was the second straight season the Atlantic Sun champion won as a big underdog, following Florida Gulf Coast's victory over Georgetown in 2013.
Final score: Mercer 78, Duke 71
9. March 21, 2002 -- Sweet 16
No. 5 Indiana Hoosiers vs. No. 1 Duke Blue Devils
Closing line: Duke minus-13
In the only Sweet 16 game to make the list, Indiana overcame a 17-point deficit to beat defending champion Duke in a wild game. It appeared over when Indiana took a four-point lead with 11.1 seconds left, but on the ensuing possession, Duke's Jason Williams was fouled while making a 3-pointer with 4.2 seconds left. He missed the free throw, though, and the Hoosiers pulled off the massive upset.
Final score: Indiana 74, Duke 73
10. March 11, 1999 -- round of 64
No. 14 Weber State Wildcats vs. No. 3 North Carolina Tar Heels
Closing line: North Carolina minus-13
North Carolina hadn't lost an opening-round game in the tournament since 1980, but it was playing a Weber State team that had the perfect formula for an upset -- an unbelievable individual performance and great 3-point shooting. The individual performance came from Harold Arceneaux, who carried the Wildcats with 36 points -- nearly half of the team's total. The Wildcats made 14 of their 26 3-pointers, including 7 of 10 in the second half. The win gave Weber State its second win as a 14-seed over a 3-seed in five years; it is the only team to win more than one game as a 14 over a 3 in tournament history.
Final score: Weber State 76, North Carolina 74
Honorable mention
March 29, 1999 -- national championship game
No. 1 Connecticut Huskies vs. No. 1 Duke Blue Devils
Closing line: Duke minus-9.5
In the past 20 seasons, the biggest underdog to win a national championship game was Connecticut in 1999, when it snapped Duke's 32-game winning streak as a 9.5-point underdog. UConn did not trail for the final 14:25, winning its first national title behind 27 points from Richard Hamilton. The Huskies were underdogs twice all season in 1998-99 -- by 9.5 points against Duke, and by 11 points against Maryland earlier in the season. Both times they won outright.
Final score: Connecticut 77, Duke 74
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