Finally you give me 1 study to look at...been asking for weeks. Dont know why this was so hard. I have an hour or so to look this over and i'm just gonna type out as we go
- Prospective observational? in what world is a observational study prospective? Its like they added that word to the title to make think ppl this is a higher quality study than it really is. This is a retrospective observational study
-now to the authors. Quick google search shows that some of them are in FLCCC or whatever and that is not in the COI. Speaking of COI....they write "the authors declare no conflict of interest regarding the drug, ivermectivn, and potential benefits......or any other related gains" then go on to explain they work for a drug company that manufactures IVM. Some real juggling going on there....its almost like they knew if they left the first sentence off the COI, like they should have, that people would think they have bias.
-Last but not least on the authors one of the authors Dr Cadegiani has been accused of "crimes against humanity" Holy good start batman, havent even read it yet.
Violations of medical ethics and human rights committed in a trial of an experimental drug touted by President Jair Bolsonaro as a cure for covid-19 were the worst in Brazil’s history, the country’s research regulator has said.1 The clinical trial of proxalutamide “disrespected almost the...
www.bmj.com
ok...now on to the study..
- the confounders are not robust enough esp to control for risk of getting covid...they control for risk of death, but if they dont control for risk of acquisition its not well controlled
- This is not a quasi-randomized study... needs to be truely prospective to be considered that.
- It looks like they really don't know if the control took ivm or not and if the ivm arm did or not. There is no data on f/u with any of these pts...so in reality the control and investigational arm could be taking the same amount of drug.
- Figure 2 the non-IVM group had 99 hospitalized pts and 79 deaths. A 80% mortality rate for control patients?!?!?! really adds up.....
- Many and i mean many missiong CI...would need those to get through peer reviewed
now to the limitations/conclusion
- to claim the limitations that they saw and say it is likely to benefit is a huge red flag...even if someone truely believed that they would never...and i mean never make that sort of claim. There conclusion is from fairly land
but wow this is one terrible paper...the thought that you think this is any sort of "evidence" for use of IVM is laughable....really it is, this is a sad paper to use as evidence. This paper could (stress could) be used to direct further studies, but we have good RCTs and they show that it doesn't work.
@Joes Place please feel free to add more