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COVID raises risk of long-term brain injury, large U.S. study finds

Dec 31, 2014
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@GOHOX69


CHICAGO, Sept 22 (Reuters) - People who had COVID-19 are at higher risk for a host of brain injuries a year later compared with people who were never infected by the coronavirus, a finding that could affect millions of Americans, U.S. researchers reported on Thursday.

The year-long study, published in Nature Medicine, assessed brain health across 44 different disorders using medical records without patient identifiers from millions of U.S. veterans.

...

"The results show the devastating long-term effects of COVID-19," senior author Dr. Ziyad Al-Aly of Washington University School of Medicine said in a statement.

...

"Memory impairments, commonly referred to as brain fog, were the most common symptom. Compared with the control groups, people infected with COVID had a 77% higher risk of developing memory problems.

People infected with the virus also were 50% more likely to have an ischemic stroke, which is caused by blood clots, compared with the never infected group.

Those who had COVID were 80% more likely to have seizures, 43% more likely to have mental health issues, such as anxiety or depression, 35% more likely to have headaches and 42% more likely to suffer movement disorders, such as tremors, compared with the control groups
."
 
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Reuters, eh? Russian propaganda.
Don't know if you are being cheeky or seriously dismissing it.

"Al-Aly and colleagues at Washington University School of Medicine and the Veterans Affairs St. Louis Health Care System studied medical records from 154,000 U.S. veterans who had tested positive for COVID from March 1, 2020 to Jan. 15, 2021.

They compared these with records from 5.6 million patients who did not have COVID during the same time frame, and another group of 5.8 million people from the period just before the coronavirus arrived in the United States.
"
 
"Given the colossal scale of the pandemic, meeting these challenges requires urgent and coordinated - but, so far, absent - global, national and regional response strategies,” Al-Aly said.

Coordinated will never happen.
 
It was a jab at @torbee. He claims Reuters is Russian propaganda.
Newsweek is the really bad one: Well, the zombie publication they are calling Newsweek now.

Reuters is fairly middle-of-the-road, a little less reliable than AP.

That said, Reuters does SHARE too much Russian propaganda due to its uncomfortably close relationship with TASS:

Employees at one of the most well-known news wire services are privately fuming over their company’s ongoing partnership with a Russian state-controlled media organization that has published unverified information about the war in Ukraine.

Multiple journalists at Reuters told POLITICO that staff are frustrated and embarrassed by the company’s continued partnership with Tass, the wire service owned by the Russian government. The relationship dates back to 2020, when the news wire first announced a partnership to distribute content from the state-owned news organization. That move raised some eyebrows among staff at Reuters at the time. But it passed largely unnoticed by people outside the company. In the wake of the Ukraine invasion, more scrutiny is being placed on the arrangement, including from Reuters’ employees.

 
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@GOHOX69


CHICAGO, Sept 22 (Reuters) - People who had COVID-19 are at higher risk for a host of brain injuries a year later compared with people who were never infected by the coronavirus, a finding that could affect millions of Americans, U.S. researchers reported on Thursday.

The year-long study, published in Nature Medicine, assessed brain health across 44 different disorders using medical records without patient identifiers from millions of U.S. veterans.

...

"The results show the devastating long-term effects of COVID-19," senior author Dr. Ziyad Al-Aly of Washington University School of Medicine said in a statement.

...

"Memory impairments, commonly referred to as brain fog, were the most common symptom. Compared with the control groups, people infected with COVID had a 77% higher risk of developing memory problems.

People infected with the virus also were 50% more likely to have an ischemic stroke, which is caused by blood clots, compared with the never infected group.

Those who had COVID were 80% more likely to have seizures, 43% more likely to have mental health issues, such as anxiety or depression, 35% more likely to have headaches and 42% more likely to suffer movement disorders, such as tremors, compared with the control groups
."
There is evidence to this and ironically my lab is studying exactly this. We have developed a brain organoid model to study this. I'll let you know which neurons or accessory cells or both are lost!
The sequelae you have listed are true!
 
There is evidence to this and ironically my lab is studying exactly this. We have developed a brain organoid model to study this. I'll let you know which neurons or accessory cells or both are lost!
The sequelae you have listed are true!
I make OP's mom sequelae on the reg.
 
@GOHOX69


CHICAGO, Sept 22 (Reuters) - People who had COVID-19 are at higher risk for a host of brain injuries a year later compared with people who were never infected by the coronavirus, a finding that could affect millions of Americans, U.S. researchers reported on Thursday.

The year-long study, published in Nature Medicine, assessed brain health across 44 different disorders using medical records without patient identifiers from millions of U.S. veterans.

...

"The results show the devastating long-term effects of COVID-19," senior author Dr. Ziyad Al-Aly of Washington University School of Medicine said in a statement.

...

"Memory impairments, commonly referred to as brain fog, were the most common symptom. Compared with the control groups, people infected with COVID had a 77% higher risk of developing memory problems.

People infected with the virus also were 50% more likely to have an ischemic stroke, which is caused by blood clots, compared with the never infected group.

Those who had COVID were 80% more likely to have seizures, 43% more likely to have mental health issues, such as anxiety or depression, 35% more likely to have headaches and 42% more likely to suffer movement disorders, such as tremors, compared with the control groups
."
Just like playing sports, drinking, drug use......

And after two years, someone thinks they've got a claim on what "long term" affects there MIGHT be?
 
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Just like playing sports, drinking, drug use......

And after two years, someone thinks they've got a claim on what "long term" affects there MIGHT be?
Umm no. In this case, the virus is directly responsible for either neuronal death in the cerebral cortex, death of accessory cells such as microglia, persistent inflammation leading to cell death or something else. There is no "thinking" involved in science, just data. The data clearly shows that some people have neural insults due to Sars-Cov-2. Nothing nebulous about that.
 
Just like playing sports, drinking, drug use......

And after two years, someone thinks they've got a claim on what "long term" affects there MIGHT be?
I mean, "just like" other than everything you mentioned being voluntary activities and contracting a virus being involuntary.

Some might say that's a wee bit of difference :rolleyes:
 
Umm no. In this case, the virus is directly responsible for either neuronal death in the cerebral cortex, death of accessory cells such as microglia, persistent inflammation leading to cell death or something else. There is no "thinking" involved in science, just data. The data clearly shows that some people have neural insults due to Sars-Cov-2. Nothing nebulous about that.
GFY fancy elitist scientist guy!
 
@GOHOX69


CHICAGO, Sept 22 (Reuters) - People who had COVID-19 are at higher risk for a host of brain injuries a year later compared with people who were never infected by the coronavirus, a finding that could affect millions of Americans, U.S. researchers reported on Thursday.

The year-long study, published in Nature Medicine, assessed brain health across 44 different disorders using medical records without patient identifiers from millions of U.S. veterans.

...

"The results show the devastating long-term effects of COVID-19," senior author Dr. Ziyad Al-Aly of Washington University School of Medicine said in a statement.

...

"Memory impairments, commonly referred to as brain fog, were the most common symptom. Compared with the control groups, people infected with COVID had a 77% higher risk of developing memory problems.

People infected with the virus also were 50% more likely to have an ischemic stroke, which is caused by blood clots, compared with the never infected group.

Those who had COVID were 80% more likely to have seizures, 43% more likely to have mental health issues, such as anxiety or depression, 35% more likely to have headaches and 42% more likely to suffer movement disorders, such as tremors, compared with the control groups
."

Not only this - new study shows it slows down neuron regeneration in the brain, which can significantly accelerate neurodegenerative processes, like Alzheimer's.

Loss of neurorengenerative functions may be a root cause of "brain fog".




Abstract

Since the hippocampus is predominantly susceptible to injuries caused by COVID-19, there are increasing data indicating the likelihood of post-infection memory loss and quickening neurodegenerative disorders, such as Alzheimer’s disease. This is due to the fact that the hippocampus has imperative functions in spatial and episodic memory as well as learning. COVID-19 activates microglia in the hippocampus and induces a CNS cytokine storm, leading to loss of hippocampal neurogenesis. The functional and structural changes in the hippocampus of COVID-19 patients can explain neuronal degeneration and reduced neurogenesis in the human hippocampus. This will open a window to explain memory and cognitive dysfunctions in “long COVID” through the resultant loss of hippocampal neurogenesis.

Conclusion

The hippocampus, which is important in memory, spatial working memory through transient high gamma synchrony, executive functions, path integration, and spatial processing, is recognized as one of the earliest and most distressed configurations of the brain throughout acute or chronic inflammatory circumstances owing to its specific susceptibility to neuroinflammatory incidents. This is also the case in COVID-19, which activates microglia in the hippocampus and induces a CNS cytokine storm, leading to the loss of hippocampal neurogenesis. The details of functional and structural changes of the hippocampus in COVID-19 patients, which were explored in this review, explain memory and cognitive dysfunctions in “long COVID” through the loss of hippocampal neurogenesis. The initial results of a longitudinal investigation on the assessment of episodic verbal memory have also practically illustrated weaker performance in COVID-19 patients than in healthy controls. This clinical outcome additionally confirms the role of the hippocampus in cognitive function in COVID-19 patients.
A better perspective of the cellular features of COVID-19 brain injury could assist in interventions to ease long-term neuropsychiatric complaints. These therapeutic aids may include antagonists of cytokines or other pathway modulators. Alleviating the long-term post–COVID-19 complications of cognition, emotion, and behavior would help reduce the disease burden. The neuropathology of COVID-19 may provide a replica for decoding the neurodegenerative mechanisms related to neuroinflammation in other brain diseases and for developing new therapeutic methods.



FYI: vaccination reduces your risks of Long Covid by ~3x to ~6x.
 
You know, if Covid dropped the average IQ of people infected 10-20 points, it would explain a lot of what the **** is happening in our country and in the world the last 18-24 months.
 
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