You've got to be somewhat careful with that. In our "20 second sound clip" society, if she has one good retort, that's what will be on an endless loop the next day. Keep in mind most Americans cannot be bothered to watch these debates, nor do they even particularly understand the issues being debated (math behind fiscal problems, who's who in the foreign policy sphere, etc).
As far as I can tell, the Republicans need to get better answers on climate change as that's clearly one of the top 3 talking points. Gun control is a debate, but the Republicans can get past that by saying "we agree, more background checks, next issue". Looking at Obamacare, the Republicans already own that issue (it has been a total disaster and people know it) so they just need to remind people that the Democrats gave that to them. Foreign policy is an area the Republicans need to hone a bit, as the left has crafted an image that the right just wants to "fight wars". Meanwhile, the right has cast the left as paper tigers who draw red lines and don't defend them.