One Antibody To Rule Them All

Joes Place

HR King
Aug 28, 2003
New antibody neutralizes all known SARS-CoV-2 variants in lab tests

Antibodies in three of the nine families strongly neutralized the original Wuhan-Hu-1 virus. But one antibody family, and especially an antibody dubbed SP1-77, showed much broader activity, neutralizing alpha, beta, gamma, delta, and all previous and current omicron strains.

“SP1-77 binds the spike protein at a site that so far has not been mutated in any variant, and it neutralizes these variants by a novel mechanism,” noted Kirchhausen. “These properties may contribute to its broad and potent activity.”

This work was supported by the Howard Hughes Medical Institute, the Bill & Melinda Gates Foundation (INV-021989), the National institutes of Health (NIAID Consortia for HIV/AIDS Vaccine Development UM1-AI144371, P01 AI158571, Maximizing Investigators’ Research Award GM130386, Harvard Virology Program training grant T32 AI07245), Massachusetts Consortium on Pathogen Readiness (MassCPR) SARS-CoV-2 Variants Award, Emergent Ventures fast grant, FDA (MCMi grant #OCET 2021-1565 and Perinatal Health Center of Excellence project grant #GCBER005), the Danish Technical University and SANA, and IONIS.