Yes, especially the Trump GOP cult members. You could look it up, of course, but the states that continue to have the worst issues are those who have GOP governors who ignorantly bow to the sage medical advice of Guru Trump.
No strategy will work if a significant number of people refuse to follow it.
You could have the greatest offensive coordinator in the history of football, but if 3 or 4 of the 11 offensive players consistently believe they know better and do whatever the hell they want on every play, I don't think the offense is going to work very well.
I believe it was Knute Rockne, or maybe it was Hayden Fry, who said, "Fools rush in where angels fear to tread." Or maybe it was Alexander Pope back in 1711....