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The Dirty Drug and the Ice Cream Tub: The Story of Rapamycin and mTOR

Joes Place

HR King
Aug 28, 2003
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Fascinating Radiolab Podcast from my recent feeds.

This episode, a tale of a wonder drug that will make you wonder about way more than just drugs.
Doctor-reporter Avir Mitra follows the epic and fantastical journey of a molecule dug out of a distant patch of dirt that would go on to make billions of dollars, prolong millions of lives, and teach us something fundamental we didn’t know about ourselves. Along the way, he meets a geriatric mouse named Ike, an immigrant dad who’s a little bit cool sometimes, a prophetic dream that prompts a thousand-mile journey, an ice cream container that may or may not be an accessory to international drug smuggling, and - most important of all - an obscure protein that’s calling the shots in every one of your cells RIGHT NOW.


This drug would have never existed, had a key scientists (and immigrant) not rescued it from a garbage can and smuggled it along with him to his new job. Bayer "decided" it was worthless, and scuttled the project, but a scientist who wanted to understand how it worked, figured it out.

You can google more about rapamycin and mTOR to read about them as well.
 
Our lab actively examines mTOR targets, especially in relation to oncology applications and cell-signaling.
 
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