Woman who had CAR-T cell therapy for neuroblastoma 18 yrs ago still in remission

[Joes Place]

Woman who had pioneering cancer treatment 18 years ago still in remission

Researchers say woman treated for neuroblastoma as a child is longest known survivor after having CAR T-cell therapy

www.theguardian.com

Elno and his buddies are shutting down NIH grants for therapies like these this month.

Currently, there are 1873 CAR-T cell studies in the ClinicalTrials.gov database.
Some of them will now shut down.

Others will no longer start now.

ClinicalTrials.gov

clinicaltrials.gov

 

[Aardvark86]

Woman who had pioneering cancer treatment 18 years ago still in remission

Researchers say woman treated for neuroblastoma as a child is longest known survivor after having CAR T-cell therapy

www.theguardian.com

Elno and his buddies are shutting down NIH grants for therapies like these this month.

Currently, there are 1873 CAR-T cell studies in the ClinicalTrials.gov database.
Some of them will now shut down.

Others will no longer start now.

ClinicalTrials.gov

clinicaltrials.gov

While you're certainly right in an absolute sense that "some" will be affected, I think you're probably more wrong than right as to CAR-T being a particularly good poster child here. The concept has been proven, products have made it to market (notwithstanding how unbelievably complicated CAR-T is), huge amounts are invested in the platform infrastructure, and this is the primary example of a platform actually holding promise for scalability. Ergo, industry and academia are all in on this. (FWIW, about 100 of the 1800 studies in the db are government funded, about 1/10 of those have been terminated, and another 40 are not recruiting new participants.)

 

[Joes Place]

While you're certainly right in an absolute sense that "some" will be affected, I think you're probably more wrong than right as to CAR-T being a particularly good poster child here. The concept has been proven, products have made it to market (notwithstanding how unbelievably complicated CAR-T is), huge amounts are invested in the platform infrastructure, and this is the primary example of a platform actually holding promise for scalability. Ergo, industry and academia are all in on this. (FWIW, about 100 of the 1800 studies in the db are government funded, about 1/10 of those have been terminated, and another 40 are not recruiting new participants.)

The point being that many dozens of therapies LIKE this start out as basic science work.
And it can take years (often decades) of investment, before something that is a viable "production" therapy is commercialized.

mRNA vaccines are a perfect example, being funded by federal grants for upwards of 2 decades before Pfizer commercialized one. Now, we have a half dozen or more companies making them.

W/o the funding that is now being removed, stuff like this will no longer happen, because no company will invest 20 yrs of work into something they cannot identify a clear path to commercialization for.

Is this point not clear, or do you simply disagree with it?

 

[Aardvark86]

The point being that many dozens of therapies LIKE this start out as basic science work.
And it can take years (often decades) of investment, before something that is a viable "production" therapy is commercialized.

mRNA vaccines are a perfect example, being funded by federal grants for upwards of 2 decades before Pfizer commercialized one. Now, we have a half dozen or more companies making them.

W/o the funding that is now being removed, stuff like this will no longer happen, because no company will invest 20 yrs of work into something they cannot identify a clear path to commercialization for.

Is this point not clear, or do you simply disagree with it?

No, my point is simply that CAR-T is not a particularly good bloody shirt to wave as to that point.

 

[Joes Place]

No, my point is simply that CAR-T is not a particularly good bloody shirt to wave as to that point.

Neither were mRNA vaccines 15+ yrs ago.

 

[Aardvark86]

Neither were mRNA vaccines 15+ yrs ago.

while i'm no vaccine denier, i'm not sure that's the greatest example to introduce to this particular message board.

 

[Joes Place]

while i'm no vaccine denier, i'm not sure that's the greatest example to introduce to this particular message board.

I'm sure you can identify at least dozen others, though.
Pretty much every standard therapy being used at the Steadman Children's hospital started out this same way, and none of them would exist today w/o the federal "seed" funding working out the details.