I've never done it and wouldn't want to do it for an extended period of time but I'd give an off-road RV a try for a trip. With that said, the thought has crossed my mind to buy one of these for my truck. The wife no pics and I both love camping and road trips and have discussed taking a trip out west to hike and sightsee.
I doubt we ever do it, at least this way. But the idea has been discussed quite a few times because I was incredibly close to buying one back before I met her when I was single.