The play design isn't the problem. It's the read and execution.
Give Iowa State credit for dropping their safeties to take away the deep ball and essentially making the throwback what it ended up being. Even if Cade puts enough on it to make the back shoulder throw, the safety would've been there to pick it off or at least force a breakup or a ridiculous catch by Lachey with no YAC, which isn't what the play is suppose to do.
The other part of it, besides the bad read by Cade, was that the play was poorly executed by the two receivers on the rollout side, moreso on whoever the deeper target was. They were right on top of each other and there was nothing there.
But if you look closely, had the crossing receiver actually been instructed to drift up/or not run the wrong lazy flatter route, he actually would've been, BY DESIGN (not just wishful armchair QB'ing), behind the defender, AND ISU was actually keying on that play call, so their safeties who were in drop coverage were, A. Middle of the field, and B. Taking away the backside fade.
Whoever the deeper receiver was could've had a huge gain had he recognized where he was at on the field (or had they schemed that play better, as we don't necessarily know what they were coached to do on those routes), but I can promise you had the deeper of the two receivers ran more of a deep cross/post, it then would've been on Cade to break off the throwback, see the open receiver and make the lob pass to what would've been an open receiver, who then would've been in a foot race with their middle safety.
That's always been the problem though with Kirk's players. Way too robotic, and just putting their heads down and running into brick walls because that's what the instructions say to f***ing do.........................🙃