The return of the Woolly Mammoth
- Thread starter Chishawk1425
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As much as we can sequence yes. There are large chunks that could be mammoth or contamination.
Although their dataset consists of more than four-billion DNA bases, only 3.3 billion of them -- a little over the size of the human genome -- currently can be assigned to the mammoth genome. Some of the remaining DNA bases may belong to the mammoth, but others could belong to other organisms, like bacteria and fungi, from the surrounding environment that had contaminated the sample. The team used a draft version of the African elephant's genome, which currently is being generated by scientists at the Broad Institute of MIT and Harvard, to distinguish those sequences that truly belong to the mammoth from possible contaminants.
Scientists Sequence Woolly-Mammoth Genome
(PhysOrg.com) -- Scientists at Penn State are leaders of a team that is the first to report the genome-wide sequence of an extinct animal, according to Webb Miller, professor of biology and of computer science and engineering and one of the project's two leaders. The scientists sequenced the...
As much as we can sequence yes. There are large chunks that could be mammoth or contamination.
Although their dataset consists of more than four-billion DNA bases, only 3.3 billion of them -- a little over the size of the human genome -- currently can be assigned to the mammoth genome. Some of the remaining DNA bases may belong to the mammoth, but others could belong to other organisms, like bacteria and fungi, from the surrounding environment that had contaminated the sample. The team used a draft version of the African elephant's genome, which currently is being generated by scientists at the Broad Institute of MIT and Harvard, to distinguish those sequences that truly belong to the mammoth from possible contaminants.
Scientists Sequence Woolly-Mammoth Genome
(PhysOrg.com) -- Scientists at Penn State are leaders of a team that is the first to report the genome-wide sequence of an extinct animal, according to Webb Miller, professor of biology and of computer science and engineering and one of the project's two leaders. The scientists sequenced the...phys.org
But we can fill those in with it's closest living relatives
You can try. There was a team trying to convert a chicken into a dinosaur. More power to them.
Sorry for the questions but why wouldn't a frozen wolly mammoth have fully intact DNA?As much as we can sequence yes. There are large chunks that could be mammoth or contamination.
Although their dataset consists of more than four-billion DNA bases, only 3.3 billion of them -- a little over the size of the human genome -- currently can be assigned to the mammoth genome. Some of the remaining DNA bases may belong to the mammoth, but others could belong to other organisms, like bacteria and fungi, from the surrounding environment that had contaminated the sample. The team used a draft version of the African elephant's genome, which currently is being generated by scientists at the Broad Institute of MIT and Harvard, to distinguish those sequences that truly belong to the mammoth from possible contaminants.
Scientists Sequence Woolly-Mammoth Genome
(PhysOrg.com) -- Scientists at Penn State are leaders of a team that is the first to report the genome-wide sequence of an extinct animal, according to Webb Miller, professor of biology and of computer science and engineering and one of the project's two leaders. The scientists sequenced the...
DNA, especially genomic DNA, which you might know as chromosomes, is prone to shear stress due to its size. In most living cells, that DNA is coiled around proteins called histones in a tight chromatin state. If it weren't, its size would overwhelm the space available in the cell and chunks would start breaking off.
Loss of "hunks" of DNA is precisely why some leukemias start, due to chromosomal translocation, and as we age our telomeres (end of the chromosomes) get less faithfully replicated (copied) and each cycle you loose a little bit of genetic info, leading to well eventual disease and death.
I bet. Let's get this sucker cloned. Let's do Manbearpig first.
so there is no way all of their chromosomes would survive, intact, after long term freezing even if it had never thawed?
Not a chance in hades. If you do have further interest, there are kits available on amazon or some such, where you can isolate genomic DNA from onions or a hunk of meat etc. If you have kids or have your own interest, try it out. You can actually see genomic DNA (not the base pairs) as a snotty looking substance.
Tissue-->Alkaline lysis (i.e. soap)-->Neutralization-->Alcohol-->Isolated DNA.
If it's the same team they were able to grow a chicken embryo that had teeth, IIRC
If your'e not at work and not the squeamish sort, google teratoma. It's a type of a tumor. It's got interesting things in it. Hair, teeth, glands, like a surprise smorgasboard.I can grow your own teeth
I can grow your own teeth
True, but they resurrected genes buried for 65 million years...mind blowing
Study of Chicken Teeth Sheds Light on Evolution
Single genes, sure. No problem with that. They have even ressurected things like bacteria, yeast, fungi etc. Intact organisms that can handle dormancy and form cysts are quite doable (and perhaps deadly).
We've even made artificial bacteria.
Because we don't have reliable full length genomic sequence and even if we did, we cannot generate 3x109 base pairs of DNA using synthetic biology. Some day yes, now even 10,000 base pairs per run is a stretch.
You know someone is going to try and clone Thomas Jefferson or something.
You can bet when the technology does advance, that mankind will be incapable of using it responsibly.
You can bet when the technology does advance, that mankind will be incapable of using it responsibly.
Hah, they'd do Hitler before TJ
And of course, one the genie is out, it's out. Don't worry. You and I will be long dead before that happens.My sibling has one of these wrapped around their brainstem. VERY rare. When they operated they said it had hair and teeth. They told them that is had been there since utero. Sibling is doing ok,...but will always have to have it checked and might have to have more surgeries later on.
Well I’m not individually an “expert” based on my own academic credentials, but I am a primary shareholder in a CLIA approved high complexity laboratory, a molecular reactor based advanced pharmaceutical ingredient manufacturing company, the company that makes said molecular reactors and I am hopefully setting up an academic program for training in the above as well as on campus API and fill and finish pharmaceutical company in the Tampa Bay Area. My FiL is a former med school Dean who’s currently teaching Crispr and related tech and was one of the principals in developing Taxol at FSU. X And I’m a huge dinosaur nerd that takes special trips out to Montana, Kansas and Utah to take part in Public digs to grab my own fossils for my decent sized collection.
So I’m not an expert, but expert “adjacent”. And the research says…yeah it’s possible.
I hope your sibling has a long and happy and healthy life. All the best to you and your family!
GOHOX69. I can tell you are extremely bright and think your field of work is amazing. So, I am interested in what your thoughts would be on these questions.
Is it possible that someone, somewhere currently has a cure for Cancer (somewhere...hidden away)?
If not, do you think a cure for ANY type of cancer is close?
Thanks!!!!!
Is it possible that someone, somewhere currently has a cure for Cancer (somewhere...hidden away)?
If not, do you think a cure for ANY type of cancer is close?
Thanks!!!!!
Is it possible to cure cancer? Yes. Regardless of profit motive and fame, I don't think 99.99% of scientists would hide a cure from the general public. We do our job to help others and see them get better. We don't do it for money. We get paid shit wages but are in the trenches to reverse horrible diseases. So, no I don't think anything is being hidden. I will say though that the FDA and the current clinical trial system is way too slow and compassionate use of new novel agents, too onerous to get into the patient. That has to change but that is a combination of non-scientific factors.
Are we close? Yes. Cancer, as you have rightly stated, is a heterogenous group of diseases with similar outcomes, in that cells become malignant, form tumors and ultimately metastasize and kill the individual. There are many new agents that now starting clinical trials. These include immunotherapy, checkpoint inhibitors and most recently and excitingly, exosomes and micro RNA's. These shut down tumors by shutting down aberrant signalling in tumor cells.
Again, the pace is exceedingly slow, and for most patients, the time from diagnosis to death is about 2 years. It doesn't make a whit of difference to them and that's pretty damn sad. That's an indictment on my field and the guilt I live with.
But long story short, yes I think revolutionary changes are coming!
My son had ALL leukemia as a child.
As I understand it. Some breakthrough was made in treatment in the 80's and since then the survival rate has increased incrementally.
My son survived what would have been a death sentence in 1973.
How far are we from actually being able to do the Hugh Jackman trick from The Prestige where he drowns a clone of himself every night?
We're closer to making human clones than cloning an extinct creature. However, a clone means a genetically identical individual, not one who necessarily looks the same. Most people imagine clones to be identical. We can't do that yet but if you give me a cheek swab, I can make any and all tissues you possess. That includes your sperm. And those primitive stem cells are immortal and can be stored in liquid nitrogen forever, long after you're dead. In a 100 years, those cells can be readily thawed and by then identical clones and man/machine hybrids will be routine.
Yes many advances have been made. Now, car-t therapy is commonly used to cure, yes cure, leukemia.
I'm very happy your son is doing well!
That was a great and disturbing movie.
Thank you SO MUCH for the response!!! It gives me hope for everyone who has this disease!!! I am glad you and others like you are on the front line. So, let me take the opportunity to say a heartfelt "Thank you"!!! And you all should get paid WAY MORE then what you do...even though that is not why you are in this fight....
So very glad to hear your son made it through his battle!!!!
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