mRNA Vaccines That Code For the Spike Protein--Both Moderna and Pfizer

[GOHOX69]

Food for thought


https://www.pnas.org/content/117/41/25254

We show that SARS-CoV-2 spike contains sequence and structure motifs highly similar to those of a bacterial superantigen and may directly bind T cell receptors. We further report a skewed T cell receptor repertoire in COVID-19 patients with severe hyperinflammation, in support of such a superantigenic effect. Notably, the superantigen-like motif is not present in other SARS family coronaviruses, which may explain the unique potential for SARS-CoV-2 to cause both MIS-C and the cytokine storm observed in adult COVID-19.


https://www.ahajournals.org/doi/full/10.1161/JAHA.120.016219

They also discovered that injection of the SARS‐CoV Spike protein alone could decrease lung ACE2 expression and cause acute lung injury, which can be alleviated by ACEIs/ARBs. Considering that the configuration of Spike protein of SARS‐CoV and SARS‐CoV‐2 is almost the same, SARS‐CoV‐2 infection might also downregulate the ACE2 expression in the lung, which might take part in the pathological process of the lung injury.

 

[anon_01irjibf16qqj]

Explain this to me like I am 5

 

[Tenacious E]

Food for thought


https://www.pnas.org/content/117/41/25254

We show that SARS-CoV-2 spike contains sequence and structure motifs highly similar to those of a bacterial superantigen and may directly bind T cell receptors. We further report a skewed T cell receptor repertoire in COVID-19 patients with severe hyperinflammation, in support of such a superantigenic effect. Notably, the superantigen-like motif is not present in other SARS family coronaviruses, which may explain the unique potential for SARS-CoV-2 to cause both MIS-C and the cytokine storm observed in adult COVID-19.


https://www.ahajournals.org/doi/full/10.1161/JAHA.120.016219

They also discovered that injection of the SARS‐CoV Spike protein alone could decrease lung ACE2 expression and cause acute lung injury, which can be alleviated by ACEIs/ARBs. Considering that the configuration of Spike protein of SARS‐CoV and SARS‐CoV‐2 is almost the same, SARS‐CoV‐2 infection might also downregulate the ACE2 expression in the lung, which might take part in the pathological process of the lung injury.

 

[GOHOX69]

S protein vaccines, which are the basis of Pfizer and modernas approach might be inherently dangerous. Both use mrna to code for portions of the spike protein.

 

[Tenacious E]

S protein vaccines, which are the basis of Pfizer and modernas approach might be inherently dangerous. Both use mrna to code for portions of the spike protein.

 

[JMNSHO]

S protein vaccines, which are the basis of Pfizer and modernas approach might be inherently dangerous. Both use mrna to code for portions of the spike protein.

Soooo.........Zombie apocalypse?

 

[mnole03]

S protein vaccines, which are the basis of Pfizer and modernas approach might be inherently dangerous. Both use mrna to code for portions of the spike protein.

 

[Chishawk1425]

What, still no clue. Help. This isn't a good sign for people hoping this is the answer as is with just this batch of vaccine then or what?

 

[GOHOX69]

What I am saying is there are other approaches that are in parallel, namely the Oxford vaccine. Those approaches are using a pseudotyped virus where a virus that causes the common cold, Adenovirus, expresses the spike protein. In that sense, the spike protein is tethered and self-contained, as opposed to giving your cells carte blanche to producing what is potentially a toxic protein and calling that a vaccine. Personally, I'd take the pseudotyped vaccine and even then, only if it were a killed variant and not attenuated. This risk is even greater for older folks and those with underlying conditions that might cause a weakened immune system.

 

[GOHOX69]

I mean Pfizer's shit must work right?

Oops, I sold some stock

 

[hawkeyez]

@GOHOX69 are you telling me I should be selling my Moderna stock (up 20% in the last 5 days)?

 

[torbee]

That paper was written in March and published in September. I am going to presume the vaccine researchers are well aware of the issues raised.

 

[GOHOX69]

@GOHOX69 are you telling me I should be selling my Moderna stock (up 20% in the last 5 days)?

Pump and dump. Hold till data

 

[GOHOX69]

That paper was written in March and published in September. I am going to presume the vaccine researchers are well aware of the issues raised.

Not really to be honest. We are running like chickens with our heads cut off due to public pressure. And peer review in science is not expedited just because of a pandemic. Those vaccine approaches were greenlighted in the March time frame, not 2 months ago.

 

[anon_01irjibf16qqj]

I still don't know what's happening in this thread

 

[Moral]

I still don't know what's happening in this thread

I'm just giving likes so it seems like I know what is going on.

 

[GOHOX69]

I still don't know what's happening in this thread

All I am saying is don't believe what you necessarily hear and use good and sound judgment and get all the facts.

 

[Tenacious E]

What I am saying is there are other approaches that are in parallel, namely the Oxford vaccine. Those approaches are using a pseudotyped virus where a virus that causes the common cold, Adenovirus, expresses the spike protein. In that sense, the spike protein is tethered and self-contained, as opposed to giving your cells carte blanche to producing what is potentially a toxic protein and calling that a vaccine. Personally, I'd take the pseudotyped vaccine and even then, only if it were a killed variant and not attenuated. This risk is even greater for older folks and those with underlying conditions that might cause a weakened immune system.

 

[GOHOX69]

Here's it in simple terms. Let Moderna and Pfizer release their full data sets and actual immunological data v. adverse events instead of saying "x percent effective."

 

[BioHawk]

I love this thread. It's the antithesis of the wouldja threads.

 

[anon_01irjibf16qqj]

Here's it in simple terms. Let Moderna and Pfizer release their full data sets and actual immunological data v. adverse events instead of saying "x percent effective."

You could have just said, no I don't speak it

 

[RunRonnieRun]

I'm a gambler...I'll still get the shot when I can.

 

[goldmom]

So there's still hope for my J&J stock?

 

[shank hawk]

What I am saying is there are other approaches that are in parallel, namely the Oxford vaccine. Those approaches are using a pseudotyped virus where a virus that causes the common cold, Adenovirus, expresses the spike protein. In that sense, the spike protein is tethered and self-contained, as opposed to giving your cells carte blanche to producing what is potentially a toxic protein and calling that a vaccine. Personally, I'd take the pseudotyped vaccine and even then, only if it were a killed variant and not attenuated. This risk is even greater for older folks and those with underlying conditions that might cause a weakened immune system.

So you use a ‘cousin’ of corona: the adenovirus, to stimulate the immune system which allows your T-cell (inherent) immune defenses to act?

It might not reach the hoped-for 90% efficacy but will do some (much?) good with an improved safety outlook. Makes sense.

 

[desihawk]

I still don't know what's happening in this thread

My translation of OP's position on this vaccine

 

[GOHOX69]

My translation of OP's position on this vaccine

You are correct sir.

 

[Ozzy4335]

S protein vaccines, which are the basis of Pfizer and modernas approach might be inherently dangerous. Both use mrna to code for portions of the spike protein.

The article says the downregulation of ACEII and lung damage from the injection of the spike protein can be alleviated by Ace Inhibitors and ARB's (ie losartan, etc). The oxford vaccine you mention uses a primate adenovirus. Give me the MRNA jab and a few days of low dose (10 mg) lisinopril and you can have the Monkey Shot. (planet of the Apes anyone?!?) The second article you mention was written in April. A the MRNA vaccine isn't an injection of the spike protein it is an introduction of the RNA. The body takes the MRNA and manufactures a covid shaped spike protein, not an actual spike protein.

 

[bladel]

That paper was written in March and published in September. I am going to presume the vaccine researchers are well aware of the issues raised.

Pfizer's Phase 3 study group has over 40,000 volunteers. Moderna is about 30,000. Figure half got placebos, that means 35k people have been vaccinated with these two mRNA candidates. And there are other mRNA candidates in the works as well.

My point is: I think we would've heard more about these risks. And the studies would've been paused or halted if large numbers of subjects started getting sick.

 

[GOHOX69]

The article says the downregulation of ACEII and lung damage from the injection of the spike protein can be alleviated by Ace Inhibitors and ARB's (ie losartan, etc). The oxford vaccine you mention uses a primate adenovirus. Give me the MRNA jab and a few days of low dose (10 mg) lisinopril and you can have the Monkey Shot. (planet of the Apes anyone?!?) The second article you mention was written in April. A the MRNA vaccine isn't an injection of the spike protein it is an introduction of the RNA. The body takes the MRNA and manufactures a covid shaped spike protein, not an actual spike protein.

Covid shaped spike protein? Dude, I know what mRNA does. It produces a portion of the "actual" Sars-CoV-2 S protein. I get that much. Thanks for the primer.

DNA==>mRNA==>Protein

I'm not that slow on the uptake chief. The mRNA sequence is based on the coding sequence for the "actual" S protein.

 

[artradley]

I still don't know what's happening in this thread

Vaccines don't work, infected people don't have immunity, there's probably lots of unknown additional side effects to COVID that will kill you later.

We are all going to die.

 

[UKGrad93]

So Idtdna wasn't involved?

 

[UKGrad93]

Vaccines don't work, infected people don't have immunity, there's probably lots of unknown additional side effects to COVID that will kill you later.

We are all going to die.

Yep. Eventually.

 

[Tom Paris]

I'm just giving likes so it seems like I know what is going on.

LOL!!!

 

[GOHOX69]

So Idtdna wasn't involved?

Not in this. Fyi idt got acquired 2 years ago or so for 2.9 billion dollars. It's now technically a larger company called Danaher.

 

[anon_01irjibf16qqj]

Not in this. Fyi idt got acquired 2 years ago or so. It's now technically a larger company called Danaher.

Was Theranos involved?

 

[GOHOX69]

Was Theranos involved?

Haha no only her fake deep voice.

 

[Ozzy4335]

Covid shaped spike protein? Dude, I know what mRNA does. It produces a portion of the "actual" Sars-CoV-2 S protein. I get that much. Thanks for the primer.

DNA==>mRNA==>Protein

I'm not that slow on the uptake chief. The mRNA sequence is based on the coding sequence for the "actual" S protein.

You've speculated on something. Show me the white paper that says MRNA vaccines cause lung damage.

 

[GOHOX69]

You've speculated on something. Show me the white paper that says MRNA vaccines cause lung damage.

Do you know how to read and think for yourself? Read the two papers and extrapolate. Surely you can do that. And I've speculated as much as the companies have shared data which is slim to none.

 

[GOHOX69]

You've speculated on something. Show me the white paper that says MRNA vaccines cause lung damage.

And you can show me a single paper on a successful mrna vaccine currently being used, for anything, by anybody. Go ahead.

 

[Ozzy4335]

Do you know how to read and think for yourself? Read the two papers and extrapolate. Surely you can do that. And I've speculated as much as the companies have shared data which is slim to none.

And you haven't shared any data either. You just post 2 random articles that do not say anything about MRNA covid vaccines causing lung damage. Are you some sort of anti-vaccine Trumpanzee?