A few things they could do to neutralize Ott. The short passing game, obviously. Those quick hitters and slants and pitch-outs to the WRs in the flats take away the pass rush because the ball is out in 2 seconds or less and it basically becomes 4 on 7 or 5 on 7 depending on if ISU goes empty or has a RB. And if you're going to one side that basically cuts the defense in half in terms of being able to react to the initial pass. It then falls on the DBs and LBs in coverage to make plays/break up passes at some point before the opponent reaches the endzone......
Another would be the screen to the RB that Illinois State liked to run. The only danger of that is that if a team reads it well, they can blow it up in the backfield, and you risk the possibility of Ott pulling a Christian Ballard and picking the ball off. Ott does have a blocked punt return for a TD in his career. It'd be nice if he could add to that before his senior season ends.
Lastly, ISU could just simply run away from Ott like scared little babies, just like a lot of teams did with Clayborn (yes, it's smart football but I'll make fun of them anyway because I can
). He bullrushed right by the Illinois State OTs early and often, but what that also creates is a lane to step up in the pocket or a hole for the RB if the rest of the DL/LBs do not adjust their containment. Or they could also just more often than not attack Meier and Bazata and see if they're capable of making the Cyclones think twice about picking on them.