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The Dark Side of mRna vaccines

In response to the first outbreak in late February 2020, the New Zealand Government closed the country's borders and imposed lockdown restrictions. A four-tier alert level system was introduced on 21 March 2020 to manage the outbreak within New Zealand.

Maybe if Trump was allowed to do that...

Again: NOT what I'm referring to.

They have one of the HIGHEST vaccination rates of anywhere. That has resulted in FEW Covid deaths, and even LOWER death rates above expected values (UNLIKE other places, where it is very possible Covid sequelae are a primary reason for them).

IF Covid vaccines were harmful, New Zealand would be one of the places you would look. And when you look, you find NOTHING THERE.
 
So you making a point by posting information from NIH is different than you claiming the information?
LOLWUT?

I posted what had been up on their site for WEEKS at the time.
Why don't you stay on topic here, and acknowledge mRNA vaccines are FINE, because if they caused excess deaths, we would be seeing that NOW in New Zealand. Only NZ has LOWER excess deaths than most places.

Which is most likely a combo of minimizing outbreaks in the first place AND vaccinating most of their population with a safe and effective vaccine. Pfizer, to be specific.
 
Again: NOT what I'm referring to.

They have one of the HIGHEST vaccination rates of anywhere. That has resulted in FEW Covid deaths, and even LOWER death rates above expected values (UNLIKE other places, where it is very possible Covid sequelae are a primary reason for them).

IF Covid vaccines were harmful, New Zealand would be one of the places you would look. And when you look, you find NOTHING THERE.
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New Zealand and Australia were Covid success stories. Why are they behind on vaccine rollouts?
By Julia Hollingsworth, CNN
Updated 10:50 PM EDT, Thu April 15, 2021

(CNN)Over the past year, New Zealand has been celebrated for its handling of the Covid-19 pandemic.

As other countries battled months-long lockdowns and hospital systems on the brink of collapse, New Zealand imposed a five-week nationwide lockdown before returning to something resembling normality. Although borders have been closed to foreigners for more than a year, music festivals and weddings have gone ahead. The country has reported around 2,500 cases and 26 deaths.

It was a similar story in other parts of Asia-Pacific -- so much so that when Australian think tank Lowy Institute scored more than 100 countries on their Covid-19 performance earlier this year, it found Asia-Pacific had, on average, been the most-successful region in the world at containing the pandemic.


The two worst regions, according to the Lowy Institute, were Europe and the Americas -- and leaders in United States and United Kingdom, in particular, were seen as catastrophic failures in their handling of the pandemic.

But as the world enters a new phase of pandemic measures, the tables are somewhat turning.

Now, the US and UK are leading the world in their mass vaccination campaigns, while some Asia-Pacific countries that won praise for containing the virus are lagging.

Already, 37% of Americans have received at least one dose, and CNN analysis estimates the country could achieve herd immunity through vaccines by the summer -- something that would probably require 70% to 85% of people to be vaccinated.

The United Kingdom, which became the first country to administer a fully tested vaccine in December, has already at least partially vaccinated 47% of its population.

Participants take part in a mock Covid-19 vaccination drill in Seoul, South Korea.
Participants take part in a mock Covid-19 vaccination drill in Seoul, South Korea.
By contrast, New Zealand, Thailand, Taiwan, South Korea and Japan -- all relatively successful at preventing large-scale outbreaks -- have each vaccinated less than 4% of their populations. Australia, which once planned to have its population vaccinated by the end of this year, now says it won't be setting any targets. As of April 12, Australia had vaccinated just 1.2 million people -- less than 5% of its population. New Zealand is the second lowest in the OECD in terms of the number of Covid-19 vaccines administered.

The situation differs for each country, but experts say one reason is where they are in the queue -- these Asia-Pacific countries just didn't sign agreements with manufacturers for vaccines as early as others.

While leaders are defending their slow rollout, saying there's value in waiting to see how the vaccines work in other countries that need them more, experts are urging them to speed up immunization or risk being left behind.

A bold gamble in the US and UK
In the early months of the pandemic, some Asia-Pacific countries took similar, successful approaches -- tough border restrictions, swift lockdowns, widespread testing and efficient contact tracing.

Meanwhile, outbreaks in Europe and the Americas spun out of control. Desperate to deal with the unfolding crises, some hard-hit countries began focusing their efforts on vaccines.

Robert Carnell, regional head of research for Asia-Pacific for financial services company ING, said countries that threw money at vaccine developers have since reaped the benefits.
 
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New Zealand and Australia were Covid success stories. Why are they behind on vaccine rollouts?
Why are you posting 2021 stories?

New Zealand has one of the MOST vaccinated populations. That is fully substantiated FACT.
They did NOT have excess mortality rates due to vaccines. Also FACT.
 
For the year 2022, New Zealand reported the biggest increase in registered deaths in over a hundred years (think Spanish Flu), an increase of 10.4%! Of course, they blame a lot of it on covid even though super smart people realize there's hardly any covid in NZ due to their extremely high rates of vaccination (New Zealand Herald, 2/19/23).

And since there's hardly any covid it can't be covid sequelea doing this damage. Hmm, maybe it's fallout from a new medical phenomenon known as Silent Long-Covid Sequelea...

And 2023 doesn't look a whole lot better; trending towards a 7-8% increase in deaths over 2021. Someone needs to re-think their narrative.
 
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For the year 2022, New Zealand reported the biggest increase in registered deaths in over a hundred years
That's the year Covid hit them, spud.

And even with vaccines, Covid still kills many people. And NZ had FAR fewer Covid deaths per capita than most other countries. Vaccines are not 100% effective, in case you missed that.

Go look it up: vaccines are NOT related at all to what you are posting. That's what NZ's health ministry has even said.
 
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And since there's hardly any covid
Huh?

NZ had Covid outbreaks. But since they were mostly protected by vaccines, those outbreaks resulted far FEWER deaths than they would have had.

Again: Go visit and/or email their Health Ministry if you don't believe me. Send your tripe to them, and see what they tell you. Are you going to claim their own Health Ministry is "owned by Pfizer" now?
 
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Joe was proven wrong again

Uh, no

If anyone has clear evidence of "mRNA vaccines" being extremely dangerous, they have yet to publish those findings in any major medical or science journal. A blockbuster like that would end up in one of the Nature publications.
 
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Joe was proven wrong again and he's not taking it well.
1) New Zealanders are one of the most vaccinated populations in the world. 2) Being vaxxed and boosted is 95% effective* at reducing severe outcomes. 3) Despite these two givens, people are dropping like flies in 2022 and 2023 from........covid?

Either A) it's NOT covid they're dying from, or B) they're lying about how effective the covid 'vaccines' are.

Hmmm, whichever could it be? 😉

*https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2796615
 
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1) New Zealanders are one of the most vaccinated populations in the world. 2) Being vaxxed and boosted is 95% effective* at reducing severe outcomes. 3) Despite these two givens, people are dropping like flies in 2022
They didn't "drop like flies" in 2022.

The "5%" the vaccines weren't effective for were the ones who died.

You continue to post nonsense here. If you take issue with what the NZ Health Ministry says, then contact them, yourself.
 
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New Zealand was slammed in 2022 with the following catastrophic and deadly side effects of Omicron (per the WHO):
  • Runny nose.
  • Cough.
  • Headache.
  • Mild or severe fatigue.
  • Sore throat.
  • Sneezing
And then one of the 'most heavily vaccinated countries on earth reported their deadliest year in over a hundred years...and is following up in '23 with a close second.

Nope. Nothing to see here.
 
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New Zealand was slammed in 2022 with the following catastrophic and deadly side effects of Omicron (per the WHO)
Yeah; that's when the virus hit them

And they still suffered excess deaths. But BECAUSE most had been vaccinated, they had FAR FEWER per capita than the US did.

See? You're LEARNING!!!!
 
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Vaccine and mask bitching still going on. It's like groundhog day here
No, people are just making damn sure people acknowledge who was right and who was wrong all along. The people who were wrong deserve to sit in their own shit and then some for the types of BS that were spewing from their keyboard 2-3 years ago.

It's worth repeating as much as it takes so we don't want to have to go through this BS again, as some elites are actually saying it will.
 
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EdhLZ1bWsAAPGtT
 
Oh, gawd... did this thread come up again? Y'all conspiracy nuts are cray
 
[April 15, 2021]

Already, 37% of Americans have received at least one dose, and CNN analysis estimates the country could achieve herd immunity through vaccines by the summer -- something that would probably require 70% to 85% of people to be vaccinated.
Ah, the good old days when there was still some hope of achieving herd immunity.

Was that ever a real possibility? Suppose, for example, we had all the vaccines we needed, great distribution, high compliance, and minimal resistance.
 
Ah, the good old days when there was still some hope of achieving herd immunity.

Was that ever a real possibility?

Nope.

We did not understand that Covid actually mutates FASTER than influenza AND has more mammalian reservoirs to mutate in.

Researchers had HOPED that would be the case, on the assumption Covid would mutate far slower than it actually does.

That does not mean "vaccines are useless"; far from it. They can lower our seasonal infection rates by a lot, if people get them.
 
Hey I see you're finally catching on. A lot of the people who were touting the vaccines ARE dead now! Took ya long enough!
1.18 million US dead.

I wonder how many were eligible to vote and what their party preference was.

My favorite conspiracy theory is that the COVID Pandemic was created by the Democrats AND that the Democrats propagated vaccine resistance among Republican voters. Just think about it....

1. Mostly kills off the elderly, making Medicare and Social Security secure for an extra decade into the future.

2. Mostly kills Republicans, and the most right wing Republicans, at that.

3. Makes more people wish for universal health care.
 
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Hey I see you're finally catching on. A lot of the people who were touting the vaccines ARE dead now! Took ya long enough!
It's sad, really.

So many people unknowingly conned into taking injections that literally destroy their immunity (https://pubmed.ncbi.nlm.nih.gov/37243095/) and the system put in place as an early warning detector of vaccine flaws is now being used to hide the dangers (https://www.bmj.com/content/383/bmj.p2582).

Oh, well. As long as Pfizer makes a profit I guess...

We propose a hypothetical immune tolerance mechanism induced by mRNA vaccines, which could have at least six negative unintended consequences:

(1) By ignoring the spike protein synthesized as a consequence of vaccination, the host immune system may become vulnerable to re-infection with the new Omicron subvariants, allowing for free replication of the virus once a re-infection takes place. In this situation, we suggest that even these less pathogenic Omicron subvariants could cause significant harm and even death in individuals with comorbidities and immuno-compromised conditions.

(2) mRNA and inactivated vaccines temporally impair interferon signaling [142,143], possibly causing immune suppression and leaving the individual in a vulnerable situation against any other pathogen. In addition, this immune suppression could allow the re-activation of latent viral, bacterial, or fungal infections and might also allow the uncontrolled growth of cancer cells [144].

(3) A tolerant immune system might allow SARS-CoV-2 persistence in the host and promote the establishment of a chronic infection, similar to that generated by the hepatitis B virus (HBV), the human immune deficiency virus (HIV), and the hepatitis C virus (HCV) [145].

(4) The combined immune suppression (produced by SARS-CoV-2 infection [15,16,17,18,19,20,21,22] and further enhanced by vaccination [142,143,144]) could explain a plethora of autoimmune conditions, such as cancers, re-infections, and deaths temporally associated with both. It is conceivable that the excess deaths reported in several highly COVID-19-vaccinated countries may be explained, in part, by this combined immunosuppressive effect.

(5) Repeated vaccination could also lead to auto-immunity: in 2009, the results of an important study went largely unnoticed. Researchers discovered that in mice that are otherwise not susceptible to spontaneous autoimmune disorders, repeated administration of the antigen promotes systemic autoimmunity. The development of CD4+ T cells that can induce autoantibodies (autoantibody-inducing CD4+ T cells, or aiCD4+ T cells), which had their T cell receptors (TCR) modified, was triggered by excessive stimulation of CD4+ T cells. The aiCD4+ T cell was generated by new genetic TCR modification rather than a cross-reaction. The excessively stimulated CD8+ T cells induced them to develop into cytotoxic T lymphocytes (CTL) that are specific for an antigen. These CTLs were able to mature further by antigen cross-presentation, so in that situation, they induced autoimmune tissue damage resembling systemic lupus erythematosus (SLE) [146]. According to the self-organized criticality theory, when the immune system of the host is continually overstimulated by antigen exposure at concentrations higher than the immune system’s self-organized criticality can tolerate, systemic autoimmunity inevitably occurs [147].

It has been proposed that the amount and duration of the spike protein produced are presumably affected by the higher mRNA concentrations in the mRNA-1273 vaccine (100 µg) compared to the BNT162b2 vaccine (30 µg) [31]. Thus, it is probable that the spike protein produced in response to mRNA vaccination is too high and lasts too long in the body. That could overwhelm the capacity of the immune system, leading to autoimmunity [146,147]. Indeed, several investigations have found that COVID-19 immunization is associated with the development of autoimmune responses [148,149,150,151,152,153,154,155,156,157,158,159,160,161,162,163,164,165,166].

(6) Increased IgG4 levels induced by repeated vaccination could lead to autoimmune myocarditis; it has been suggested that IgG4 antibodies can also cause an autoimmune reaction by impeding the immune system’s ability to be suppressed by regulatory T cells [102]. Patients using immune checkpoint inhibitors alone or in combination have been linked to occurrences of acute myocarditis [103,104,105,106,107], sometimes with lethal consequences [102]. As anti-PD-1 antibodies are class IgG4, and these antibodies are also induced by repeated vaccination, it is plausible to suggest that excessive vaccination could be associated with the occurrence of an increased number of myocarditis cases and sudden cardiac deaths.
 
It's sad, really.

So many people unknowingly conned into taking injections that literally destroy their immunity (https://pubmed.ncbi.nlm.nih.gov/37243095/)

Boy, ain't that a Who's Who of top notch immunologists!!??? (Not)

  • Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
  • 2Biological Science Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.
  • 3Therapeutic and Protective Proteins Laboratory, Protein Research Department, Genetic Engineering and Biotechnology Research Institute, City for Scientific Research and Technology Applications, New Borg EL-Arab, Alexandria 21934, Egypt.
  • 4Cross Cancer Institute, Alberta Health Services, 11560 University Avenue, Edmonton, AB T6G 1Z2, Canada.
  • 5Autlan Regional Hospital, Health Secretariat, Autlan 48900, Jalisco, Mexico.
  • 6Biology Laboratory, Autlan Regional Preparatory School, University of Guadalajara, Autlan 48900, Jalisco, Mexico.
 
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It's sad, really.

So many people unknowingly conned into taking injections that literally destroy their immunity (https://pubmed.ncbi.nlm.nih.gov/37243095/)
Meanwhile....back in RealityLand (and loads of Cochrane-related sources, considered the Gold Standard for research)


Authors' conclusions: Compared to placebo, most vaccines reduce, or likely reduce, the proportion of participants with confirmed symptomatic COVID-19, and for some, there is high-certainty evidence that they reduce severe or critical disease. There is probably little or no difference between most vaccines and placebo for serious adverse events. Over 300 registered RCTs are evaluating the efficacy of COVID-19 vaccines, and this review is updated regularly on the COVID-NMA platform (covid-nma.com). Implications for practice Due to the trial exclusions, these results cannot be generalized to pregnant women, individuals with a history of SARS-CoV-2 infection, or immunocompromized people. Most trials had a short follow-up and were conducted before the emergence of variants of concern. Implications for research Future research should evaluate the long-term effect of vaccines, compare different vaccines and vaccine schedules, assess vaccine efficacy and safety in specific populations, and include outcomes such as preventing long COVID-19. Ongoing evaluation of vaccine efficacy and effectiveness against emerging variants of concern is also vital.


Affiliations​

  • 1Cochrane France, Paris, France.
  • 2Centre of Research in Epidemiology and Statistics (CRESS), INSERM, INRAE, Université de Paris, Paris, France.
  • 3Cochrane Review Group on Drugs and Alcohol, Rome, Italy.
  • 4Cochrane Response, Cochrane, London, UK.
  • 5Department of Immunization, Vaccines and Biologicals, World Health Organization, Geneva, Switzerland.
  • 6Evidence Synthesis Ireland, Cochrane Ireland and HRB-Trials Methodology Research Network, National University of Ireland, Galway, Ireland.
  • 7UCD Centre for Experimental Pathogen Host Research and UCD School of Medicine, University College Dublin, Dublin, Ireland.
  • 8Department of Clinical Immunology and Infectious Diseases, Henri Mondor Hospital, Vaccine Research Institute, Université Paris Est Créteil, Paris, France.
  • 9Quality Assurance Norms and Standards Department, World Health Organization, Geneva, Switzerland.
  • 10Cochrane South Africa, South African Medical Research Council, Cape Town, South Africa.
  • 11Institute for Evidence in Medicine, Medical Center & Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • 12Cochrane Germany, Cochrane Germany Foundation, Freiburg, Germany.
  • 13Department of Anesthesia, Intensive Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
  • 14Epistemonikos Foundation, Santiago, Chile.
  • 15UC Evidence Center, Cochrane Chile Associated Center, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • 16Centre for Evidence Based Medicine Odense (CEBMO) and Cochrane Denmark, University of Southern Denmark, Odense, Denmark.
  • 17Open Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark.


Conflict of interest statement​

Carolina Graña: none known.
Lina Ghosn: none known.
Theodoros Evrenoglou: none known.
Alexander Jarde: none known.
Silvia Minozzi: no relevant interests; Joint Co‐ordinating Editor and Method editor of the Drugs and Alcohol Group.
Hanna Bergman: Cochrane Response – consultant; WHO – grant/contract (Cochrane Response was commissioned by the WHO to perform review tasks that contribute to this publication).
Brian Buckley: none known.
Katrin Probyn: Cochrane Response – consultant; WHO – consultant (Cochrane Response was commissioned to perform review tasks that contribute to this publication).
Gemma Villanueva: Cochrane Response – employment (Cochrane Response has been commissioned by WHO to perform parts of this systematic review).
Nicholas Henschke: Cochrane Response – consultant; WHO – consultant (Cochrane Response was commissioned by the WHO to perform review tasks that contributed to this publication).
Hillary Bonnet: none known.
Rouba Assi: none known.
Sonia Menon: P95 – consultant.
Melanie Marti: no relevant interests; Medical Officer at WHO.
Declan Devane: Health Research Board (HRB) – grant/contract; registered nurse and registered midwife but no longer in clinical practice; Editor, Cochrane Pregnancy and Childbirth Group.
Patrick Mallon: AstraZeneca – Advisory Board; spoken of vaccine effectiveness to media (print, online, and live); works as a consultant in a hospital that provides vaccinations; employed by St Vincent's University Hospital.
Jean‐Daniel Lelievre: no relevant interests; published numerous interviews in the national press on the subject of COVID vaccination; Head of the Department of Infectious Diseases and Clinical Immunology CHU Henri Mondor APHP, Créteil; WHO (IVRI‐AC): expert Vaccelarate (European project on COVID19 Vaccine): head of WP; involved with COVICOMPARE P et M Studies (APHP, INSERM) (public fundings).
Lisa Askie: no relevant interests; Co‐convenor, Cochrane Prospective Meta‐analysis Methods Group.
Tamara Kredo: no relevant interests; Medical Officer in an Infectious Diseases Clinic at Tygerberg Hospital, Stellenbosch University.
Gabriel Ferrand: none known.
Mauricia Davidson: none known.
Carolina Riveros: no relevant interests; works as an epidemiologist.
David Tovey: no relevant interests; Emeritus Editor in Chief, Feedback Editors for 2 Cochrane review groups.
Joerg J Meerpohl: no relevant interests; member of the German Standing Vaccination Committee (STIKO).
Giacomo Grasselli: Pfizer – speaking engagement.
Gabriel Rada: none known.
Asbjørn Hróbjartsson: no relevant interests; Cochrane Methodology Review Group Editor.
Philippe Ravaud: no relevant interests; involved with Mariette CORIMUNO‐19 Collaborative 2021, the Ministry of Health, Programme Hospitalier de Recherche Clinique, Foundation for Medical Research, and AP‐HP Foundation.
Anna Chaimani: none known.
Isabelle Boutron: no relevant interests; member of Cochrane Editorial Board.


Awful lot of "no conflicts" listed there....
 
109 million US dead.

I wonder how many were eligible to vote and what their party preference was.

My favorite conspiracy theory is that the COVID Pandemic was created by the Democrats AND that the Democrats propagated vaccine resistance among Republican voters. Just think about it....

1. Mostly kills off the elderly, making Medicare and Social Security secure for an extra decade into the future.

2. Mostly kills Republicans, and the most right wing Republicans, at that.

3. Makes more people wish for universal health care.
But, the false positives, and the people who died with COVID and not of COVID. Don't those work hand-in-hand to over-inflate inflate those numbers?
 
I know people who got vaxxed and didn't fare as well. And everyone who I know is unvaxxed didn't have any severe side effects and are still alive as well. We don't have to worry about our hearts or stroke either.

Let's just say I've been observing very closely the development of the vaccinated vs unvaccinated kids that I know and noticing the significant differences. Could it be coincidence? Yes, but I doubt it.
Never change.
 
These characterizations of the cited reports are wrong and dishonest.

That said, the reports themselves, along with the rest of your post are worth a look.
Thanks. There's more you know... ;)

A Cochrane Vaccines Field analysis19 evaluated studies measuring the benefits of flu vaccination. The analysis, published in the BMJ, concludes: “The large gap between policy and what the data tell us (when rigorously assembled and evaluated) is surprising… Evidence from systematic reviews shows that inactivated vaccines have little or no effect on the effects measured… Reasons for the current gap between policy and evidence are unclear, but given the huge resources involved, a re-evaluation should be urgently undertaken.”

A review18 of more than 30 influenza vaccine studies conducted for the Cochrane Library states, “Our review findings have not identified conclusive evidence of benefit of HCW [healthcare workers] vaccination programs on specific outcomes of laboratory-proven influenza, its complications (lower respiratory tract infection, hospitalization or death due to lower respiratory tract illness), or all cause mortality in people over the age of 60.” The authors conclude, “This review does not provide reasonable evidence to support the vaccination of healthcare workers to prevent influenza.” In addition, “There is little evidence to justify medical care and public health practitioners mandating influenza vaccination for healthcare workers.”

Although some studies suggest positive effects of the flu vaccine on the incidence of illness caused by flu viruses, that benefit is potentially outweighed by the negative effects of the flu vaccine on the incidence of non-flu respiratory illness.1 To address the concern among patients that the flu vaccine causes illness (i.e., acute respiratory illness), the Centers for Disease Control and Prevention (CDC) funded a three-year study,2 published in Vaccine, to analyze the risk of illness after flu vaccination compared to the risk of illness in unvaccinated individuals.

The study, which included healthy subjects, found a 65% increased risk of non-flu acute respiratory illness within 14 days of receiving the flu vaccine. The authors state, “Patients’ experiences of illness after vaccination may be validated by these results.” The most common non-flu pathogens found were rhinovirus, enterovirus, respiratory syncytial virus, and coronaviruses.

The National Institute of Health (NIH) funded a study6 to measure the effect of seasonal influenza vaccination on hospitalization among the elderly. The study analyzed 170 million episodes of medical care and found that “no evidence indicated that vaccination reduced hospitalizations.”

Households are thought to play a major role in community spread of influenza, and there has been a long history of analyzing family households to study the incidence and transmission of respiratory illnesses of all severities. As such, the CDC funded a study9 of 1,441 participants, both vaccinated and unvaccinated, in 328 households. The study evaluated the flu vaccine’s ability to prevent community-acquired influenza (household index cases) and influenza acquired in people with confirmed household exposure to the flu (secondary cases). Transmission risks were determined and characterized.

In conclusion, the authors state: “There was no evidence that vaccination prevented household transmission once influenza was introduced.”9,10

Studies have observed that influenza vaccines have low effectiveness in individuals who are vaccinated in two consecutive years.9 A review of 17 influenza vaccine studies published in Expert Review of Vaccines states, “The effects of repeated annual vaccination on individual long-term protection, population immunity, and virus evolution remain largely unknown.”14


 
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Meanwhile....back in RealityLand (and loads of Cochrane-related sources, considered the Gold Standard for research)


Authors' conclusions: Compared to placebo, most vaccines reduce, or likely reduce, the proportion of participants with confirmed symptomatic COVID-19, and for some, there is high-certainty evidence that they reduce severe or critical disease. There is probably little or no difference between most vaccines and placebo for serious adverse events. Over 300 registered RCTs are evaluating the efficacy of COVID-19 vaccines, and this review is updated regularly on the COVID-NMA platform (covid-nma.com). Implications for practice Due to the trial exclusions, these results cannot be generalized to pregnant women, individuals with a history of SARS-CoV-2 infection, or immunocompromized people. Most trials had a short follow-up and were conducted before the emergence of variants of concern. Implications for research Future research should evaluate the long-term effect of vaccines, compare different vaccines and vaccine schedules, assess vaccine efficacy and safety in specific populations, and include outcomes such as preventing long COVID-19. Ongoing evaluation of vaccine efficacy and effectiveness against emerging variants of concern is also vital.


Affiliations​

  • 1Cochrane France, Paris, France.
  • 2Centre of Research in Epidemiology and Statistics (CRESS), INSERM, INRAE, Université de Paris, Paris, France.
  • 3Cochrane Review Group on Drugs and Alcohol, Rome, Italy.
  • 4Cochrane Response, Cochrane, London, UK.
  • 5Department of Immunization, Vaccines and Biologicals, World Health Organization, Geneva, Switzerland.
  • 6Evidence Synthesis Ireland, Cochrane Ireland and HRB-Trials Methodology Research Network, National University of Ireland, Galway, Ireland.
  • 7UCD Centre for Experimental Pathogen Host Research and UCD School of Medicine, University College Dublin, Dublin, Ireland.
  • 8Department of Clinical Immunology and Infectious Diseases, Henri Mondor Hospital, Vaccine Research Institute, Université Paris Est Créteil, Paris, France.
  • 9Quality Assurance Norms and Standards Department, World Health Organization, Geneva, Switzerland.
  • 10Cochrane South Africa, South African Medical Research Council, Cape Town, South Africa.
  • 11Institute for Evidence in Medicine, Medical Center & Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • 12Cochrane Germany, Cochrane Germany Foundation, Freiburg, Germany.
  • 13Department of Anesthesia, Intensive Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
  • 14Epistemonikos Foundation, Santiago, Chile.
  • 15UC Evidence Center, Cochrane Chile Associated Center, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • 16Centre for Evidence Based Medicine Odense (CEBMO) and Cochrane Denmark, University of Southern Denmark, Odense, Denmark.
  • 17Open Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark.


Conflict of interest statement​

Carolina Graña: none known.
Lina Ghosn: none known.
Theodoros Evrenoglou: none known.
Alexander Jarde: none known.
Silvia Minozzi: no relevant interests; Joint Co‐ordinating Editor and Method editor of the Drugs and Alcohol Group.
Hanna Bergman: Cochrane Response – consultant; WHO – grant/contract (Cochrane Response was commissioned by the WHO to perform review tasks that contribute to this publication).
Brian Buckley: none known.
Katrin Probyn: Cochrane Response – consultant; WHO – consultant (Cochrane Response was commissioned to perform review tasks that contribute to this publication).
Gemma Villanueva: Cochrane Response – employment (Cochrane Response has been commissioned by WHO to perform parts of this systematic review).
Nicholas Henschke: Cochrane Response – consultant; WHO – consultant (Cochrane Response was commissioned by the WHO to perform review tasks that contributed to this publication).
Hillary Bonnet: none known.
Rouba Assi: none known.
Sonia Menon: P95 – consultant.
Melanie Marti: no relevant interests; Medical Officer at WHO.
Declan Devane: Health Research Board (HRB) – grant/contract; registered nurse and registered midwife but no longer in clinical practice; Editor, Cochrane Pregnancy and Childbirth Group.
Patrick Mallon: AstraZeneca – Advisory Board; spoken of vaccine effectiveness to media (print, online, and live); works as a consultant in a hospital that provides vaccinations; employed by St Vincent's University Hospital.
Jean‐Daniel Lelievre: no relevant interests; published numerous interviews in the national press on the subject of COVID vaccination; Head of the Department of Infectious Diseases and Clinical Immunology CHU Henri Mondor APHP, Créteil; WHO (IVRI‐AC): expert Vaccelarate (European project on COVID19 Vaccine): head of WP; involved with COVICOMPARE P et M Studies (APHP, INSERM) (public fundings).
Lisa Askie: no relevant interests; Co‐convenor, Cochrane Prospective Meta‐analysis Methods Group.
Tamara Kredo: no relevant interests; Medical Officer in an Infectious Diseases Clinic at Tygerberg Hospital, Stellenbosch University.
Gabriel Ferrand: none known.
Mauricia Davidson: none known.
Carolina Riveros: no relevant interests; works as an epidemiologist.
David Tovey: no relevant interests; Emeritus Editor in Chief, Feedback Editors for 2 Cochrane review groups.
Joerg J Meerpohl: no relevant interests; member of the German Standing Vaccination Committee (STIKO).
Giacomo Grasselli: Pfizer – speaking engagement.
Gabriel Rada: none known.
Asbjørn Hróbjartsson: no relevant interests; Cochrane Methodology Review Group Editor.
Philippe Ravaud: no relevant interests; involved with Mariette CORIMUNO‐19 Collaborative 2021, the Ministry of Health, Programme Hospitalier de Recherche Clinique, Foundation for Medical Research, and AP‐HP Foundation.
Anna Chaimani: none known.
Isabelle Boutron: no relevant interests; member of Cochrane Editorial Board.


Awful lot of "no conflicts" listed there....
Awful lot of 'sketchy science' there. Embarrassing. 🤡

Authors' conclusions: Compared to placebo, most vaccines reduce, or likely reduce, the proportion of participants with confirmed symptomatic COVID-19, and for some, there is high-certainty evidence that they reduce severe or critical disease. There is probably little or no difference between most vaccines and placebo for serious adverse events. Over 300 registered RCTs are evaluating the efficacy of COVID-19 vaccines, and this review is updated regularly on the COVID-NMA platform (covid-nma.com). Implications for practice Due to the trial exclusions, these results cannot be generalized to pregnant women (because there were no trials for pregnant women), individuals with a history of SARS-CoV-2 infection (almost EVERYONE by now), or immunocompromized (because of the very real threat of ADE) people. Most trials had a short follow-up and were conducted before the emergence of variants of concern. Implications for research Future research should evaluate the long-term effect of vaccines, compare different vaccines and vaccine schedules, assess vaccine efficacy and safety in specific populations (why, yes. Yes they should!), and include outcomes such as preventing long COVID-19. Ongoing evaluation of vaccine efficacy and effectiveness against emerging variants of concern is also vital.
 
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